January 7, 2020

Granulosis rubra nasi is a rare condition characterised by hyperhidrosis of the nose. Granulosis Rubra Nasi (GRN) is a rare disorder of the eccrine glands. It is clinically characterized by hyperhidrosis of the central part of the face. Granulosis rubra nasi is a rare familial disease of children, occurring on the nose, cheeks, and chin, characterized by diffuse redness, persistent excessive.

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Case Reports in Dermatological Medicine

The patient was reassured taking into consideration the benign nature of the disease. Hence reassurance is what is needed. Elsevier, 2nd edition, hasi It usually resolves at puberty without any sequale. It is commonly seen in childhood but it can present in adults. Folliculitis Folliculitis nares perforans Tufted folliculitis Pseudofolliculitis barbae Hidradenitis Hidradenitis suppurativa Recurrent palmoplantar hidradenitis Neutrophilic eccrine hidradenitis.

Da Silva Manzoni, A. The pathogenesis of the disease is still unknown.

Some authors have suggested a defect in vasomotor and secretory functions of the nose. Excessive sweating may precede other changes by several years.

Beau’s lines Yellow nail syndrome Leukonychia Azure lunula shape: Alopecia areata totalis universalis Ophiasis Androgenic alopecia male-pattern baldness Hypotrichosis Telogen effluvium Traction alopecia Lichen planopilaris Trichorrhexis nodosa Alopecia neoplastica Anagen effluvium Alopecia mucinosa cicatricial alopecia: Diseases of the eccrine and apocrine sweat glands. Erythematous macules, papules, vesicles or even pustules may be seen over the sweat duct orifices.


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Acrokeratosis paraneoplastica of Bazex Acroosteolysis Bubble hair deformity Rura and recurrent infundibulofolliculitis Erosive pustular rubrs of the scalp Erythromelanosis follicularis faciei et colli Hair casts Hair follicle nevus Intermittent hair—follicle dystrophy Keratosis pilaris atropicans Kinking hair Koenen’s tumor Lichen planopilaris Lichen spinulosus Loose anagen syndrome Menkes kinky hair syndrome Monilethrix Parakeratosis pustulosa Pili Pili annulati Pili bifurcati Pili multigemini Pili pseudoannulati Pili torti Pityriasis amiantacea Plica neuropathica Poliosis Rubinstein—Taybi syndrome Setleis syndrome Traumatic anserine folliculosis Trichomegaly Trichomycosis axillaris Trichorrhexis Trichorrhexis invaginata Trichorrhexis nodosa Trichostasis spinulosa Uncombable hair syndrome Wooly hair Wooly hair nevus.

There was no history of any fluid or cheesy material coming out of the lesions and no history of itching or burning Figure 1.

Granulosis rubra nasi usually resolves spontaneously around puberty ; however, it occasionally persists indefinitely Treatment with glycopyrronium bromide cream, a topical anti-cholinergic, can improve symptoms Botulinum toxin injections have also been reported as effective.

The cause is unknown In some cases there is evidence of autosomal dominant transmission. View at Google Scholar J. Drying lotions like calamine can be tried. In rosacea there is erythema of the cheeks and nose along with telangiectasias but no hyperhidrosis of the central part of the face. Support Center Support Center. No preventive measures or complications are reported and the disease has an excellent prognosis with self resolution at puberty in most cases.


The common differential diagnoses include miliaria crystallina, hidrocystoma, rosacea, periorificial dermatitis, acne vulgaris and milia. It is commonly seen in childhood, but can also occur in adults.

Granulosis rubra nasi

Jorizzo Joseph, and R. Body odor Chromhidrosis Fox—Fordyce disease. Patient had noticed decreased sweating over the area, once vesicles started to appear. Granulosis rubra nasi is a rare condition characterised by hyperhidrosis of the nose.

G Ital Dermatol Venereol. Treatment of granulosis rubra nasi with botulinum toxin type A. Presentation is common in childhood with a peak age of presentation at 7—12 years, but adolescent and adult onset is granulosiw possible. Footnotes Source of Support: Other differential nwsi include acne vulgaris, lupus pernio, lupus erythematosus, lupus vulgaris, leishmaniasis, actinic keratosis or skin cancer, miliaria crystallina, and hidrocystoma [ 2410 ].

Topical indomethacin, drying lotions like calamine, tetracycline, cryotherapy, and X-rays temporary benefit have been described in the treatment of GRN [ 13 ]. The patient gave no history of any treatment taken before. Owing to scarcity of literature, authors could not ascertain if other authors have had similar observation of decreased sweating in late stages.

The clinical picture is very distinctive and rarely there is a problem with the diagnosis.