January 8, 2020

Granulosis rubra nasi is a rare condition characterised by hyperhidrosis of the nose. Granulosis Rubra Nasi (GRN) is a rare disorder of the eccrine glands. It is clinically characterized by hyperhidrosis of the central part of the face. Granulosis rubra nasi is a rare familial disease of children, occurring on the nose, cheeks, and chin, characterized by diffuse redness, persistent excessive.

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This website is non-profit and holds the images for educational purposes only. However, erythema over the central face was persisting. No preventive measures or complications are reported and the disease has an excellent prognosis with self resolution at puberty in most cases.

Granulosis Rubra Nasi presents with three stages: Dermis shows dilated eccrine sweat glands. Shows erythema more prominently.

Hirsutism Acquired localised generalised patterned Congenital generalised localised X-linked Prepubertal. Barber had suggested involvement of adenoids, which can provide a source of nadi at the tip of the nose [ 12 ].

Author information Article notes Copyright and License information Disclaimer. GRN usually resolves at puberty; however, rarely it may persist in adulthood. One should remember that it could be a complication of hyperhidrosis.

Rest of the mucocutaneous and systemic examination did not reveal any abnormality. A year-old male patient presented with asymptomatic lesion over nose since 2 years to the outpatient department of dermatology and leprosy. A year-old man presented with erythema gdanulosis the nose since childhood without sensitivity to sunlight. Owing to scarcity of literature, authors could not ascertain if other authors have had similar observation of decreased sweating in late stages.


This condition of the skin appendages article is a stub. Drying lotions like calamine can be tried. A biopsy of the skin lesion was done.

Here we report a case of GRN in an adult patient with very unusual histopathological presentation.

Granulosis rubra nasi

Erythema may gradually extend to involve upper lip, cheeks, and chin with sweat droplets studded over, giving glistening appearance. The clinical picture is very distinctive and rarely there is a problem with the diagnosis. National Center for Biotechnology InformationU.

Aetiology History Clinical findings Images Management. With persistent hyperhidrosis, diffuse erythema develops on nose, cheeks, and chin. In the English literature Maschkillesson and Neradow have recorded cases and the disease was not thought to be rare. Presentation is common in childhood with a peak age of presentation at 7—12 years, but adolescent and adult onset is rura possible. It is widely believed that it was first described in by Jadassohn.

Granulosis rubra nasi | Primary Care Dermatology Society | UK

It is an inflammatory dermatosis involving eccrine sweat glands of central face granulosix nose, cheeks, or chin, representing a unique sweat retention form [ 2 ]. Some authors have suggested that it is a disorder of vasomotor and secretory function of the nose.


GRN usually starts in early childhood and resolves spontaneously at puberty, but rarely it may persist [ 7 ] Males are most commonly affected. Rubrq Read Edit View history. View at Google Scholar G.

Excessive sweating may precede other changes by several years.

Andrew’s Disease of the Skin. She had first noticed redness and increased sweating over central face 10 years back. Topical indomethacin, drying masi like calamine, tetracycline, cryotherapy, and X-rays temporary benefit have been described in the treatment of GRN [ 13 ]. Patient had noticed decreased sweating over the area, once vesicles started to appear.

Rosacea can be differentiated by accentuation of the erythema by vasomotor instability, which is not a feature of GRN.

Case Reports in Dermatological Medicine

It is commonly seen in childhood, but can also occur in adults. There were no other mucocutaneous or systemic features. There rubrq dilation of blood vessels and the lymphatic vessels.