January 1, 2020

Learn more about Cissus Quadrangularis uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Cissus. Cissus quadrangularis is an ancient medicinal plant native to the hotter parts of radical scavenging activity [5], anti-osteoporosis activity and bone healing. Cissus quadrangularis L. (veld grape) is a climber plant of Vitaceae family. A case Keywords: Cissus quandranglis; Bone healing; Fracture;.

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It is popular as a joint aid for athletes, with preliminary evidence supporting this property of cissus. A phytogenic isolated steroid is believed to be the main constituent in Cissus quadrangularis. Fracture healing involves complex processes of cell and tissue proliferation and differentiation.

There was a shortening of about 2 weeks in the bone-healing duration. The study has further demonstrated that in the presence of CQ, bone mineralization takes place much earlier, when compared to that seen in quardangularis absence [ 13 ].

Ananthkumarand Mansi H. Quadrangullaris use of a cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Our thorough screening of literature available on Cissus quadrangularis depicted an interesting fact that though the plant is bkne popular remedy for a variety of ailments and a range of formulations has been marketed, little effort have been made to verify its purity, quality and efficacy through scientific screening.

A Lexicon of Medicinal Plants in India. But the risks of side effects caused by these drugs are severe [ 1 — 4 ]. Mice were weighed regularly. So, we used osteopontin as biochemical marker in our study to assess the fracture healing in patients treated with CQ.

Hospital ethical committee approved the study ref no. Mucopolysaccharides supplies raw materials for repair. In the distal femoral metaphysis, femoral diaphysis, and proximal tibia, control mice had decreased cancellous and cortical bone, while CQ-fed mice showed no significant differences in the trabecular number, thickness, and connectivity density, between Sham and OVX mice, except for cortical bone mineral content in the proximal tibia.


Indian J Med Res. The plant extract has been shown to have bone fracture healing properties in several in vivo studies. Subscribe to Table of Contents Alerts. C ONCLUSION In recent years, ethnobotanical and traditional uses of natural compounds, especially of plant origin received much attention as they quadrangulaaris well-tested for their efficacy and generally believed to be safe for human use.

Cissus quadrangularis – Scientific Review on Usage, Dosage, Side Effects |

Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. Author information Copyright and License information Disclaimer. Adesanya SA, Rene N. Current Science ; This article has been cited by other articles in PMC. No significant influence on heart rate when taken over the course of eight weeks. So, it may be that a stimulus obesity-linked proteins is required for CQ to reduce fat mass or the increase in fat mass is specific to mice and may not affect humans.

Inhibition of Bone Loss by Cissus quadrangularis in Mice: A Preliminary Report

Please review our privacy policy. For osteopontin expression, blood samples of patients were collected and send for the analysis to the Indian Institute of Toxicology Research, Lucknow, India. Scale consists of a straight line of 10 cm in length, signifying 0 – no pain, and qyadrangularis – severe pain [ Figure 1 ].

Swelling was measured by the placement of thread from anterior to posterior limit of swelling.

In vitro callus induction from stem explants of Cissus quadrangularis L. The more evidence, the more we can trust the results. The endodermis is not distinct and stele consists of a large number of vascular bundles varying in size, in each angular region, below collenchymatous patch, while rest of bundles smaller in size.

A comparison of calcium oxalate crystals isolated from callus cultures and their explant sources. Hadjod is an indigenous medicinal plant grown in India, Sri Lanka, and Africa.

We conclude that Bnoe effectively inhibited bone loss in the cancellous and cortical bones of femur and proximal tibia in these mice. Herbal remedies for mandibular fracture healing.

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Since the plant Cissus quadrangularis Linn is useful in the traditional system of medicine in treatment of various diseases, it is important to standardize it for use as a drug.


Patients on steroid therapy or immune-suppressants and suffering from any other chronic debilitating diseases, fracture with severe head injury, bone loss, and infected fracture were excluded.

Efficacy of CQ on early ossification cissud remodeling of bones have been reported and it has been observed that CQ acts by stimulation of metabolism and increased uptake of the minerals calcium, sulfur, and strontium by the osteoblasts in fracture healing. Existing therapies mainly reduce bone resorption, however, all existing quadrangullaris have severe side effects.

It has been prescribed in ayurveda as an alternative, anthelmintic, dyspeptic, digestive, tonic, analgesic in eye and ear diseases, and in the treatment of irregular menstruation and asthma. Each scan consisted of slices with an exposure time of 30 seconds per slice. The drugs were given in a double-blind fashion and the code was decoded at the end of study only or at the time of some serious side effects, noted, if any.

The plant contains ascorbic acid, mg and carotene, mg per g freshly prepared paste, in addition to calcium oxalate.

Cissus quadrangularis

Justin SR, Baby J. This page features 61 references. Systemic use of Cissus quadrangularis in rats caused complete restoration of normal composition of bone, after fracture in four weeks while the controls required six weeks. Investigator checked fracture mobility manually.

The pain was graded as mild, moderate, and severe based upon the patient’s response to visual analogue scale, wherein the subjective assessment of intensity or magnitude of pain felt by patient was recorded. This plant has triterpenoids [ 2223 ], steroids [ 2224 ] stilbenes [ 25 ], flavanoids [ 13 ], lipids [ 13 ], and several catalpols [ 13 ]. Effect of Cissus quandriagularis in accelerating healing process of experimentally fractured radius-ulna of dog: