September 7, 2020

Juvenile nasopharyngeal angiofibroma is a pathologically benign yet locally aggressive and destructive vascular lesion of head and neck. The juvenile nasopharyngeal angiofibroma (JNA) is a highly Nasoangiofibroma youth is a highly vascularized tumor almost exclusively male. Juvenile nasopharyngeal angiofibromas (JNA) are a rare benign but locally aggressive vascular tumor. Epidemiology Juvenile nasopharyngeal angiofibromas.

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This supports the hypothesis that the vascular endothelial cells may become postembryonic undifferentiated mesenchymal cells and can be induced into other mesenchymal nonhemopoitic cell phenotypes. About Blog Go ad-free.

Nasopharyngeal angiofibroma – Wikipedia

A year-old male patient presented with a painless, progressive swelling in the upper jaw since 2 weeks. The patients were advised to undergo preoperative arterial embolization prior to surgery. Radiographic management of juvenile angiofibromas. Financial support and sponsorship Nil. Case 2 Case 2. Continuous growth involves the sphenoidal sinus, nasal fossa and middle turbinate, pterygomaxillary fossa and the posterior wall of the maxillary sinus as seen in the present case.

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Preoperatively, all the three angiofibfoma were embolized and this step seems to be helpful for endoscopic approach to prevent intraoperative hemorrhage. The presence of prominent flow voids lead to a salt and pepper appearance on most sequences and are characteristic 5,6.


Angiofibrroma patient with stage IIA disease case no. Anterior bowing of the posterior maxillary wall, due to invasion of the pterygomaxillary space on axial CT, known as the Holman-Miller sign is one of the characteristic findings.

Numerous blood vessels with irregular size and shape were seen with a single lining endothelial cell layer.

The final diagnosis is achieved by histopathologic examination of tissue sections either on incisional or excisional biopsy. Hence early diagnosis not only helps in better management but also prevents recurrence of JNA. Clinical examination reveals a firm and friable mass in the nasopharynx and nose. CT images show a heterodense bella that is centered in the sphenopalatine foramen. Site of extension Case no. Preoperative embolisation of tumour may be of some use in reducing intraoperative bleeding.

Typically a lobulated non-encapsulated soft tissue mass jasofaring demonstrated centred on the sphenopalatine foramen which is often widened and usually bowing the posterior wall of the maxillary antrum anteriorly. Computed tomography CT scan showed the presence of a soft tissue mass involving the maxillary sinus, nasal cavity, and nasopharynx. Case 5 Case 5. Summary of preoperative pre-op. This page was last edited on 29 Septemberat Numbers in brackets indicate the number of patients having the particular symptom or sign.

Management of Juvenile Nasopharyngeal Angiofibroma: A Five Year Retrospective Study

They may be locally aggressive. Case 7 Case 7.

Moorthy1, 2 B. Conflicts of interest There are no conflicts of interest.

He was cured of his recurrence by way of surgery and radiotherapy. Finally, numerous inflammatory cells such as mast cells and T-lymphocytes are seen.


Treatment trends in patients during 40 years. This angiofobroma originates in the lateral wall of the nasal cavity, close to the superior border of the sphenopalatine foramen.

Thus, early diagnosis, accurate staging, and adequate treatment are essential in the management of this lesion. Please review our privacy policy.

The exact site of origin is contentious as these masses usually present when they have reached considerable size. Juvenile nasopharyngeal angiofibroma JNA or nasopharyngeal angiofibroma is an uncommon fibrovascular mass arising in the nasopharynx of prepubertal and adolescent males and exhibiting a strong tendency to bleed. National Center for Biotechnology InformationU.

After occupation of nasopharynx the NPF tissue invaded sphenoid sinus in about 8 patients. Views Read Edit View history. Srikanth Kolloju 1 Department of E. Although angiofibroma is histologically benign, it may act in an aggressive fashion characterized by recurrences that may extend into and destroy the adjacent bony structures. Retrieved from ” https: Genetic evidence for an androgen-dependent tumor?

MRI is superior to CT for detecting soft tissue extension of the tumor intracranially.